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A ryanodine receptor-like molecule expressed in the osteoclast plasma membrane functions in extracellular Ca2+ sensing.

Abstract:

Ryanodine receptors (RyRs) reside in microsomal membranes where they gate Ca2+ release in response to changes in the cytosolic Ca2+ concentration. In the osteoclast, a divalent cation sensor, the Ca2+ receptor (CaR), located within the cell's plasma membrane, monitors changes in the extracellular Ca2+ concentration. Here we show that a RyR-like molecule is a functional component of this receptor. We have demonstrated that [3H] ryanodine specifically binds to freshly isolated rat osteoclasts. ...

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Publisher copy:
10.1172/jci118197

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Journal:
Journal of clinical investigation
Volume:
96
Issue:
3
Pages:
1582-1590
Publication date:
1995-09-01
DOI:
EISSN:
1558-8238
ISSN:
0021-9738
Source identifiers:
475707

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