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Role of fibroblast migration in collagen fiber formation during fetal and adult dermal wound healing.

Abstract:

Adult dermal wounds, in contrast to fetal wounds, heal with the formation of scar tissue. A crucial factor in determining the degree of scarring is the ratio of types I and III collagen, which regulates the diameter of the combined fibers. We developed a reaction-diffusion model which focuses on the control of collagen synthesis by different isoforms of the polypeptide transforming growth factor-beta (TGF beta). We used the model to investigate the current controversy as to whether the fibrob...

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Publication status:
Published

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Authors


Sherratt, JA More by this author
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Institution:
University of Oxford
Department:
Oxford, MPLS, Mathematical Inst
Journal:
Bulletin of mathematical biology
Volume:
59
Issue:
6
Pages:
1077-1100
Publication date:
1997-11-05
DOI:
EISSN:
1522-9602
ISSN:
0092-8240
URN:
uuid:1add8013-91a7-4d20-9904-b556571a9911
Source identifiers:
31230
Local pid:
pubs:31230

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