Role of fibroblast migration in collagen fiber formation during fetal and adult dermal wound healing.
Adult dermal wounds, in contrast to fetal wounds, heal with the formation of scar tissue. A crucial factor in determining the degree of scarring is the ratio of types I and III collagen, which regulates the diameter of the combined fibers. We developed a reaction-diffusion model which focuses on the control of collagen synthesis by different isoforms of the polypeptide transforming growth factor-beta (TGF beta). We used the model to investigate the current controversy as to whether the fibrob...Expand abstract
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