Adult dermal wounds, in contrast to fetal wounds, heal with the formation of scar tissue. A crucial factor in determining the degree of scarring is the ratio of types I and III collagen, which regulates the diameter of the combined fibers. We developed a reaction-diffusion model which focuses on the control of collagen synthesis by different isoforms of the polypeptide transforming growth factor-beta (TGF beta). We used the model to investigate the current controversy as to whether the fibrob...Expand abstract
- Publication status:
- Publisher copy:
- Copyright date:
Role of fibroblast migration in collagen fiber formation during fetal and adult dermal wound healing.
If you are the owner of this record, you can report an update to it here: Report update to this record