- Abstract:
-
Adult dermal wounds, in contrast to fetal wounds, heal with the formation of scar tissue. A crucial factor in determining the degree of scarring is the ratio of types I and III collagen, which regulates the diameter of the combined fibers. We developed a reaction-diffusion model which focuses on the control of collagen synthesis by different isoforms of the polypeptide transforming growth factor-beta (TGF beta). We used the model to investigate the current controversy as to whether the fibrob...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1016/s0092-8240(97)00063-3
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- Journal:
- Bulletin of mathematical biology
- Volume:
- 59
- Issue:
- 6
- Pages:
- 1077-1100
- Publication date:
- 1997-11-05
- DOI:
- EISSN:
-
1522-9602
- ISSN:
-
0092-8240
- URN:
-
uuid:1add8013-91a7-4d20-9904-b556571a9911
- Source identifiers:
-
31230
- Local pid:
- pubs:31230
- Language:
- English
- Keywords:
- Copyright date:
- 1997
Journal article
Role of fibroblast migration in collagen fiber formation during fetal and adult dermal wound healing.
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