Spatial working memory in individuals at high risk for psychosis: longitudinal fMRI study.

Journal article

BACKGROUND: Neurocognitive impairments in executive and mnemonic domains are already evident in the pre-psychotic phases. The longitudinal dynamic course of the neurofunctional abnormalities underlying liability to psychosis and their relation to clinical outcomes is unknown. METHODS: In this study we used functional magnetic resonance imaging (fMRI) in a cohort of subjects at ultra high clinical risk for psychosis (with an "At Risk Mental State", ARMS) and in healthy controls. Images were ac...

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Authors: Fusar-Poli, P; Broome, MR; Matthiasson, P; Woolley, J; Johns, L

• Journal: Schizophrenia research
• Volume: 123
• Issue: 1
• Pages: 45-52
• Publication date: 2010-10-01
• DOI: 10.1016/j.schres.2010.06.008
• EISSN: 1573-2509
• ISSN: 0920-9964
• Language: English
• Keywords: Longitudinal Studies; Mental Status Schedule; Brain Mapping; Young Adult; Adult; Memory, Short-Term; Risk Factors; Cognition Disorders; Female; Male; Psychotic Disorders; Oxygen; Analysis of Variance; Neuropsychological Tests; Image Processing, Computer-Assisted; Humans; Brain; Magnetic Resonance Imaging