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Promoter proximal splice sites enhance transcription.

Abstract:

Reconstruction of a gene with its introns removed results in reduced levels of cytoplasmic mRNA. This is partly explained by introns promoting the export of mRNA through coupling splicing to nuclear export processes. However, we show here that splicing signals can have a direct role in enhancing gene transcription. Removal of promoter proximal splice signals from a mammalian gene or the excision of introns from two different yeast genes results in a marked reduction in levels of nascent trans...

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Publication status:
Published

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Publisher copy:
10.1101/gad.983602

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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
Journal:
Genes and development
Volume:
16
Issue:
21
Pages:
2792-2799
Publication date:
2002-11-01
DOI:
EISSN:
1549-5477
ISSN:
0890-9369
Source identifiers:
3025
Language:
English
Keywords:
Pubs id:
pubs:3025
UUID:
uuid:1ad55ec5-f6fc-4732-8cee-579cd0c219e3
Local pid:
pubs:3025
Deposit date:
2012-12-19

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