- Abstract:
-
Many different chromosomal translocations occur in man at chromosome 11q23 in acute leukaemias. Molecular analyses revealed that the MLL gene (also called ALL-1, HRX or HTRX) is broken by the translocations, causing fusion with genes from other chromosomes. The diversity of MLL fusion partners poses a dilemma about the function of the fusion proteins in tumour development. The consequence of MLL truncation and fusion has been analysed by joining exon 8 of Mll with the bacterial lacZ gene usin...
Expand abstract - Publisher copy:
- 10.1093/emboj/19.5.843
-
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- Journal:
- The EMBO journal
- Volume:
- 19
- Issue:
- 5
- Pages:
- 843-851
- Publication date:
- 2000-03-05
- DOI:
- EISSN:
-
1460-2075
- ISSN:
-
0261-4189
- URN:
-
uuid:1acdc500-a0fa-45d4-90d6-a5411f4e70d4
- Source identifiers:
-
324303
- Local pid:
- pubs:324303
- Copyright date:
- 2000
Journal article
Tumorigenesis in mice with a fusion of the leukaemia oncogene Mll and the bacterial lacZ gene.
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