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Tumorigenesis in mice with a fusion of the leukaemia oncogene Mll and the bacterial lacZ gene.

Abstract:

Many different chromosomal translocations occur in man at chromosome 11q23 in acute leukaemias. Molecular analyses revealed that the MLL gene (also called ALL-1, HRX or HTRX) is broken by the translocations, causing fusion with genes from other chromosomes. The diversity of MLL fusion partners poses a dilemma about the function of the fusion proteins in tumour development. The consequence of MLL truncation and fusion has been analysed by joining exon 8 of Mll with the bacterial lacZ gene usin...

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Publisher copy:
10.1093/emboj/19.5.843

Authors


Journal:
The EMBO journal
Volume:
19
Issue:
5
Pages:
843-851
Publication date:
2000-03-05
DOI:
EISSN:
1460-2075
ISSN:
0261-4189
URN:
uuid:1acdc500-a0fa-45d4-90d6-a5411f4e70d4
Source identifiers:
324303
Local pid:
pubs:324303

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