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Global prefrontal and fronto-amygdala dysconnectivity in bipolar I disorder with psychosis history

Abstract:

Background: Pathophysiological models of bipolar disorder postulate that mood dysregulation arises from fronto-limbic dysfunction, marked by reduced prefrontal cortex (PFC) inhibitory control. This might occur due to both disruptions within PFC networks and abnormal inhibition over subcortical structures involved in emotional processing. However, no study has examined global PFC dysconnectivity in bipolar disorder and tested whether regions with within-PFC dysconnectivity ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
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Publisher:
Elsevier Publisher's website
Journal:
Biological Psychiatry Journal website
Volume:
73
Issue:
6
Pages:
565-573
Publication date:
2013-03-15
DOI:
ISSN:
0006-3223
Source identifiers:
446009
Language:
English
Keywords:
Subjects:
Pubs id:
pubs:446009
UUID:
uuid:1acc3a2d-b871-4db0-834f-f031ca045e47
Local pid:
pubs:446009
Deposit date:
2014-01-18

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