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Journal article

Structural basis for natural product selection and export by bacterial ABC transporters

Abstract:

Bacteria under stress produce ribosomally synthesized and post-translationally modified peptides (RiPPs) to target closely related species, such as the lasso peptide microcin J25 (MccJ25). These peptides are also toxic to the producing organisms that utilize dedicated ABC transporters to achieve self-immunity. MccJ25 is exported by the Escherichia coli ABC transporter McjD through a complex mechanism of recognition that has remained elusive. Here, we used biomolecular NMR to study this intera...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1021/acschembio.8b00226

Authors


More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Physical & Theoretical Chem
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Maths, Physical & Life Sciences
Department:
Chemistry; Physical & Theoretical Chemistry Laboratory
Oxford college:
Exeter College
Role:
Author
Publisher:
American Chemical Society
Journal:
ACS Chemical Biology More from this journal
Volume:
13
Issue:
6
Pages:
1598-1609
Publication date:
2018-05-14
Acceptance date:
2018-05-14
DOI:
EISSN:
1554-8937
ISSN:
1554-8929
Pmid:
29757605
Language:
English
Keywords:
Pubs id:
pubs:852977
UUID:
uuid:1ac8b5af-12ba-438f-b6ab-457ba43a74d7
Local pid:
pubs:852977
Source identifiers:
852977
Deposit date:
2018-07-12

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