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Improved HIV-1 specific T-cell responses by short-interval DNA tattooing as compared to intramuscular immunization in non-human primates.

Abstract:

The new intradermal DNA delivery technique, termed DNA tattooing might overcome the discrepancy between the encouraging immunogenicity results obtained with DNA vaccines in murine studies and the poor results obtained in non-human primates and humans, the so called "simian barrier". Here, we demonstrate a 10- to 100-fold increase in the magnitude of vaccine specific T-cell responses in peripheral blood from DNA tattooed rhesus macaques, as compared to T-cell responses in animals immunized via...

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Publication status:
Published

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Journal:
Vaccine More from this journal
Volume:
26
Issue:
26
Pages:
3346-3351
Publication date:
2008-06-01
DOI:
EISSN:
1873-2518
ISSN:
0264-410X
Language:
English
Keywords:
Pubs id:
pubs:26575
UUID:
uuid:1ac140ca-4881-44c9-8c86-d28ea87048a9
Local pid:
pubs:26575
Source identifiers:
26575
Deposit date:
2012-12-19

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