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Plasmodium falciparum: a family of sulphated glycoconjugates disrupts erythrocyte rosettes.

Abstract:

The ability of Plasmodium falciparum-infected erythrocytes to form spontaneous rosettes with uninfected red cells is a parasite adhesion property which has been associated with severe malaria. The mechanism of rosetting remains unknown, but the ability of heparin to disrupt rosettes has been recognised previously. In this paper we show that a group of sulphated glycoconjugates including sulphatide, dextran sulphate, and fucoidan are more effective rosette reversing agents than heparin and are...

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Publication status:
Published

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Publisher copy:
10.1006/expr.1994.1111

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author
Journal:
Experimental parasitology More from this journal
Volume:
79
Issue:
4
Pages:
506-516
Publication date:
1994-12-01
DOI:
EISSN:
1090-2449
ISSN:
0014-4894
Language:
English
Keywords:
Pubs id:
pubs:7432
UUID:
uuid:1abea55a-a25b-419d-a291-0d69c642702d
Local pid:
pubs:7432
Source identifiers:
7432
Deposit date:
2012-12-19

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