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Maternal HIV infection is associated with distinct systemic cytokine profiles throughout pregnancy in South African women

Abstract:

Maternal HIV infection is associated with adverse pregnancy outcomes, but the mechanisms remain unknown. The course of pregnancy is regulated by immunological processes and HIV infection and antiretroviral therapy (ART) impact key immune mechanisms, which may disrupt the immune programme of pregnancy. We evaluated a broad range of systemic cytokines at each trimester of pregnancy in 56 women living with HIV (WLHIV) and 68 HIV-negative women, who were enrolled in a prospective pregnancy cohort...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41598-021-89551-3

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Women's & Reproductive Health
Oxford college:
Linacre College
Role:
Author
More by this author
Division:
MSD
Oxford college:
Linacre College
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Sub department:
Clinical Trial Service Unit
Oxford college:
Linacre College
Role:
Author
ORCID:
0000-0003-3523-7457
Publisher:
Springer Nature
Journal:
Scientific Reports More from this journal
Volume:
11
Issue:
2021
Article number:
10079
Publication date:
2021-05-12
Acceptance date:
2021-04-24
DOI:
EISSN:
2045-2322
Language:
English
Keywords:
Pubs id:
1174370
Local pid:
pubs:1174370
Deposit date:
2021-05-06

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