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Polymorphisms in the glucokinase-associated, dual-specificity phosphatase 12 (DUSP12) gene under chromosome 1q21 linkage peak are associated with type 2 diabetes.

Abstract:

Linkage of type 2 diabetes to chromosome 1q21-q23 is well replicated across populations. In an initial 50-kb marker map (580 markers) across the linked region, one of the two strongest associations observed in Utah Caucasians was at marker rs1503814 (P < 0.00001 in pools, P < 0.004 in individuals). Based on this association, we typed additional markers and screened for sequence variation in the nearby DUSP12 gene. The strongest associations mapped to a highly conserved nongenic sequence...

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Publication status:
Published

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Publisher copy:
10.2337/db05-1369

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Journal:
Diabetes
Volume:
55
Issue:
9
Pages:
2631-2639
Publication date:
2006-09-01
DOI:
EISSN:
1939-327X
ISSN:
0012-1797
Source identifiers:
10237

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