A new class of membrane-bound chemokine with a CX3C motif.

Journal article

Chemokines direct the trafficking of white blood cells in immune surveillance, playing a key role in inflammatory and infectious diseases such as AIDS. All chemokines studied so far are secreted proteins of relative molecular mass approximately 7K-15K and fall into three families that are defined by a cysteine signature motif: CXC, CC and C (refs 3, 6, 7), where C is a cysteine and X any amino-acid residue. We report here the identification and characterization of a fourth human chemokine typ...

Expand abstract

Authors: Bazan, J; Bacon, K; Hardiman, G; Wang, W; Soo, K

• Publication status: Published
• Journal: Nature
• Volume: 385
• Issue: 6617
• Pages: 640-644
• Publication date: 1997-02-01
• DOI: 10.1038/385640a0
• EISSN: 1476-4687
• ISSN: 0028-0836
• Language: English
• Keywords: Chemokines; Chemokines, CX3C; Protein Binding; DNA, Complementary; Chromosome Mapping; Tissue Distribution; Chemokine CX3CL1; Cell Line; RNA, Messenger; Hybrid Cells; Humans; Amino Acid Sequence; Membrane Proteins; Molecular Sequence Data; Cloning, Molecular