Essential role for CD103 in the T cell-mediated regulation of experimental colitis.

Journal article

The integrin CD103 is highly expressed at mucosal sites, but its role in mucosal immune regulation remains poorly understood. We have analyzed the functional role of CD103 in intestinal immune regulation using the T cell transfer model of colitis. Our results show no mandatory role for CD103 expression on T cells for either the development or CD4+CD25+ regulatory T (T reg) cell-mediated control of colitis. However, wild-type CD4+CD25+ T cells were unable to prevent colitis in immune-deficient...

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Authors: Annacker, O; Coombes, J; Malmstrom, V; Uhlig, H; Bourne, T

• Publication status: Published
• Journal: Journal of experimental medicine
• Volume: 202
• Issue: 8
• Pages: 1051-1061
• Publication date: 2005-10-01
• DOI: 10.1084/jem.20040662
• EISSN: 1540-9538
• ISSN: 0022-1007
• Language: English
• Keywords: Colitis; Immunity, Mucosal; Antigens, CD; T-Lymphocytes, Regulatory; Mice, Mutant Strains; Mice, Knockout; Immunotherapy; Animals; T-Lymphocyte Subsets; Cell Differentiation; Antibodies, Monoclonal; Statistics, Nonparametric; Cytokines; Integrin alpha Chains; Dendritic Cells; Mice