BACKGROUND: Genetics clinical practice has paid limited attention to non-inherited aspects of cancer, namely mutations occurring during carcinogenesis. These somatic mutations are likely to be the primary determinants of cancer behaviour and treatment response, with a recent example being Her2/Neu gene status and response to Herceptin in breast cancer. AIM: To assess the feasibility of widespread testing of tumours by surveying UK histopathology and genetics laboratories. METHODS: The questi...Expand abstract
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Molecular testing for somatic cancer mutations: a survey of current and future testing in UK laboratories.
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