Molecular testing for somatic cancer mutations: a survey of current and future testing in UK laboratories.

Journal article

BACKGROUND: Genetics clinical practice has paid limited attention to non-inherited aspects of cancer, namely mutations occurring during carcinogenesis. These somatic mutations are likely to be the primary determinants of cancer behaviour and treatment response, with a recent example being Her2/Neu gene status and response to Herceptin in breast cancer. AIM: To assess the feasibility of widespread testing of tumours by surveying UK histopathology and genetics laboratories. METHODS: The questi...

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Authors: Wordsworth, S; Papanicolas, I; Buchanan, J; Frayling, I; Taylor, J

• Publication status: Published
• Journal: Journal of clinical pathology
• Volume: 61
• Issue: 3
• Pages: 373-376
• Publication date: 2008-03-01
• DOI: 10.1136/jcp.2007.048819
• EISSN: 1472-4146
• ISSN: 0021-9746
• Language: English
• Keywords: Research Support as Topic; Data Collection; Immunohistochemistry; Forecasting; Cytogenetics; Mutation; In Situ Hybridization, Fluorescence; Oligonucleotide Array Sequence Analysis; Laboratories; Great Britain; Gene Expression Profiling; Humans; Neoplasms