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Evaluation of novel combined carbogen USPIO (CUSPIO) imaging biomarkers in assessing the antiangiogenic effects of cediranib (AZD2171) in rat C6 gliomas.

Abstract:

The recently described combined carbogen USPIO (CUSPIO) magnetic resonance imaging (MRI) method uses spatial correlations in independent imaging biomarkers to assess specific components of tumor vascular structure and function. Our study aimed to evaluate CUSPIO biomarkers for the assessment of tumor response to antiangiogenic therapy. CUSPIO imaging was performed in subcutaneous rat C6 gliomas before and 2 days after treatment with the potent VEGF-signaling inhibitor cediranib (n = 12), or v...

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Publication status:
Published

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Publisher copy:
10.1002/ijc.27460

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Journal:
International journal of cancer. Journal international du cancer More from this journal
Volume:
131
Issue:
8
Pages:
1854-1862
Publication date:
2012-10-01
DOI:
EISSN:
1097-0215
ISSN:
0020-7136
Language:
English
Keywords:
Pubs id:
pubs:322750
UUID:
uuid:1aa0e7f8-3a84-4234-8d4c-584db07f7118
Local pid:
pubs:322750
Source identifiers:
322750
Deposit date:
2013-11-17

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