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A statistical approach using network structure in the prediction of protein characteristics.

Abstract:

MOTIVATION: The Majority Vote approach has demonstrated that protein-protein interactions can be used to predict the structure or function of a protein. In this article we propose a novel method for the prediction of such protein characteristics based on frequencies of pairwise interactions. In addition, we study a second new approach using the pattern frequencies of triplets of proteins, thus for the first time taking network structure explicitly into account. Both these methods are extende...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MPLS, Statistics
Journal:
Bioinformatics (Oxford, England)
Volume:
23
Issue:
17
Pages:
2314-2321
Publication date:
2007-09-05
DOI:
EISSN:
1367-4811
ISSN:
1367-4803
URN:
uuid:1a9fd9bf-0b74-47c1-ab9f-bdf2479ebfc6
Source identifiers:
97488
Local pid:
pubs:97488

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