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Febrile temperatures induce cytoadherence of ring-stage Plasmodium falciparum-infected erythrocytes.

Abstract:

In falciparum malaria, the malaria parasite induces changes at the infected red blood cell surface that lead to adherence to vascular endothelium and other red blood cells. As a result, the more mature stages of Plasmodium falciparum are sequestered in the microvasculature and cause vital organ dysfunction, whereas the ring stages circulate in the blood stream. Malaria is characterized by fever. We have studied the effect of febrile temperatures on the cytoadherence in vitro of P. falciparum-...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.172398999

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Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
99
Issue:
18
Pages:
11825-11829
Publication date:
2002-09-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:1a9f608d-42cd-4945-94e4-4e305f54c065
Source identifiers:
38333
Local pid:
pubs:38333

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