A selective activity-dependent requirement for dynamin 1 in synaptic vesicle endocytosis.

Journal article

Dynamin 1 is a neuron-specific guanosine triphosphatase thought to be critically required for the fission reaction of synaptic vesicle endocytosis. Unexpectedly, mice lacking dynamin 1 were able to form functional synapses, even though their postnatal viability was limited. However, during spontaneous network activity, branched, tubular plasma membrane invaginations accumulated, capped by clathrin-coated pits, in synapses of dynamin 1-knockout mice. Synaptic vesicle endocytosis was severely i...

Expand abstract

Authors: Ferguson, S; Brasnjo, G; Hayashi, M; Wölfel, M; Collesi, C

• Journal: Science (New York, N.Y.)
• Volume: 316
• Issue: 5824
• Pages: 570-574
• Publication date: 2007-04-01
• DOI: 10.1126/science.1140621
• EISSN: 1095-9203
• ISSN: 0036-8075
• Language: English
• Keywords: Synaptic Vesicles; Action Potentials; Dynamin III; Neurons; Synaptic Transmission; Synapses; Cell Membrane; Excitatory Postsynaptic Potentials; Presynaptic Terminals; Exocytosis; Mice; Patch-Clamp Techniques; Animals; Inhibitory Postsynaptic Potentials; Endocytosis; Microscopy, Electron; Dynamin II; Mice, Knockout; Clathrin-Coated Vesicles; Dynamin I; Electric Stimulation