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Oxidative stress mediates tau-induced neurodegeneration in Drosophila.

Abstract:

Markers of oxidative damage have been detected in brain tissue from patients with Alzheimer disease (AD) and other neurodegenerative disorders. These findings implicate oxidative injury in the neurodegenerative process, but whether oxidative stress is a cause or a consequence of neurotoxicity remains unclear. We used a Drosophila model of human tauopathies to investigate the role of oxidative stress in neurodegeneration. Genetic and pharmacological manipulation of antioxidant defense mechanis...

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Publisher copy:
10.1172/jci28769

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author
Journal:
Journal of clinical investigation More from this journal
Volume:
117
Issue:
1
Pages:
236-245
Publication date:
2007-01-01
DOI:
EISSN:
1558-8238
ISSN:
0021-9738
Language:
English
Keywords:
Pubs id:
pubs:263197
UUID:
uuid:1a948547-2871-41eb-9bb3-fa128fec97dd
Local pid:
pubs:263197
Source identifiers:
263197
Deposit date:
2012-12-19

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