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The activating NKG2D ligand MHC class I-related chain A transfers from target cells to NK cells in a manner that allows functional consequences.

Abstract:

Recently, it has become apparent that surface proteins commonly transfer between immune cells in contact. Inhibitory receptors and ligands exchange between cells during NK cell surveillance and we report here that NK cells also acquire activating ligands from target cells. Specifically, the stress-inducible activating ligand for NKG2D, MHC class I-related chain A (MICA), transferred to NK cells upon conjugation with MICA-expressing target cells. Acquisition of MICA from target cells was depen...

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Publication status:
Published

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Publisher copy:
10.4049/jimmunol.178.6.3418

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Eissmann, P More by this author
Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
178
Issue:
6
Pages:
3418-3426
Publication date:
2007-03-05
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:1a91f3d8-2f59-4778-bdec-b24be5361a74
Source identifiers:
503931
Local pid:
pubs:503931

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