DNA vaccines against human immunodeficiency virus type 1.

Journal article

Development of a vaccine against human immunodeficiency virus type 1 (HIV-1) is the main hope for controlling the acquired immunodeficiency syndrome pandemic. An ideal HIV vaccine should induce neutralizing antibodies, CD4+ helper T cells, and CD8+ cytotoxic T cells. While the induction of broadly neutralizing antibodies remains a highly challenging goal, there are a number of technologies capable of inducing potent cell-mediated responses in animal models, which are now starting to be tested in humans. Naked DNA immunization is one of them. This review focuses on the stimulation of HIV-specific T cells and discusses in the context of the current 'state-of-art' of DNA vaccines, the areas where this technology might assist either alone or as a part of more complex vaccine formulations in the HIV vaccine development.

Authors: Estcourt, M; Mcmichael, A; Hanke, T

• Publication status: Published
• Journal: Immunological reviews
• Volume: 199
• Issue: 1
• Pages: 144-155
• Publication date: 2004-06-01
• DOI: 10.1111/j.0105-2896.2004.00151.x
• EISSN: 1600-065X
• ISSN: 0105-2896
• Language: English
• Keywords: CD8-Positive T-Lymphocytes; Vaccines, DNA; Humans; CpG Islands; AIDS Vaccines; HIV-1; CD4-Positive T-Lymphocytes; Antigen Presentation; Plasmids; Acquired Immunodeficiency Syndrome