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Journal article

Decreased Serum Sirtuin-1 in COPD

Abstract:

Background

The protein deacetylase sirtuin-1 (SIRT1) is an antiaging molecule that is decreased in the lung in patients with COPD. Recently, SIRT1 was reported to be detectable in serum, but serum SIRT1 (s120S) levels have not yet been reported in patients with COPD.

Methods

Serum SIRT1 protein of all samples was measured by Western blot, and the SIRT1 protein band densities were calculated and compared with clinical parameters.

Results

Several mol...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.chest.2017.05.004

Authors


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Role:
Author
ORCID:
0000-0003-3895-5518
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
NDM Experimental Medicine
Role:
Author
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Publisher:
Elsevier Publisher's website
Journal:
Chest Journal website
Volume:
152
Issue:
2
Pages:
343-352
Publication date:
2017-05-12
Acceptance date:
2017-05-01
DOI:
EISSN:
1931-3543
ISSN:
0012-3692
Pubs id:
pubs:826138
URN:
uri:1a8e44d9-8176-4a8d-a4c8-80f1fcf4fefd
UUID:
uuid:1a8e44d9-8176-4a8d-a4c8-80f1fcf4fefd
Local pid:
pubs:826138

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