Oxidised LDL internalisation by the LOX-1 scavenger receptor is dependent on a novel cytoplasmic motif and is regulated by dynamin-2.

Journal article

The LOX-1 scavenger receptor recognises pro-atherogenic oxidised low-density lipoprotein (OxLDL) particles and is implicated in atherosclerotic plaque formation, but this mechanism is not well understood. Here we show evidence for a novel clathrin-independent and cytosolic-signal-dependent pathway that regulates LOX-1-mediated OxLDL internalisation. Cell surface labelling in the absence or presence of OxLDL ligand showed that LOX-1 is constitutively internalised from the plasma membrane and i...

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Authors: Murphy, J; Vohra, R; Dunn, S; Holloway, Z; Monaco, A

• Publication status: Published
• Journal: Journal of cell science
• Volume: 121
• Issue: Pt 13
• Pages: 2136-2147
• Publication date: 2008-07-01
• DOI: 10.1242/jcs.020917
• EISSN: 1477-9137
• ISSN: 0021-9533
• Language: English
• Keywords: Humans; Lipoproteins, LDL; Mutagenesis, Site-Directed; Signal Transduction; Protein Binding; Amino Acid Sequence; Scavenger Receptors, Class E; Endocytosis; Protein Transport; Dynamin II; Protein Structure, Tertiary; Amino Acid Motifs; Molecular Sequence Data; Hela Cells