Journal article icon

Journal article

AKR1D1 is a novel regulator of metabolic phenotype in human hepatocytes and is dysregulated in non-alcoholic fatty liver disease.

Abstract:

OBJECTIVE: Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic syndrome. Steroid hormones and bile acids are potent regulators of hepatic carbohydrate and lipid metabolism. Steroid 5β-reductase (AKR1D1) is highly expressed in human liver where it inactivates steroid hormones and catalyzes a fundamental step in bile acid synthesis.

METHODS: Human liver biopsies were obtained from 34 obese patients and AKR1D1 mRNA expre...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1016/j.metabol.2019.153947

Authors


More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Sub department:
OCDEM
Oxford college:
Keble College
Role:
Author
ORCID:
0000-0002-8789-8436
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Role:
Author
Expand authors...
Publisher:
Elsevier Publisher's website
Journal:
Metabolism
Volume:
99
Pages:
67-80
Publication date:
2019-07-19
Acceptance date:
2019-07-18
DOI:
EISSN:
1532-8600
ISSN:
0026-0495
Pmid:
31330134
Source identifiers:
1033833
Language:
English
Keywords:
Pubs id:
pubs:1033833
UUID:
uuid:1a8b67f7-ca2f-4645-b0a0-c1edfe7b811e
Local pid:
pubs:1033833
Deposit date:
2019-09-06

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP