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Pyronaridine–Artesunate versus Mefloquine plus Artesunate for Malaria

Abstract:

BACKGROUND: Pyronaridine-artesunate is an artemisinin-based combination therapy under evaluation for the treatment of Plasmodium falciparum and P. vivax malaria. METHODS: We conducted a phase 3, open-label, multicenter, noninferiority trial that included 1271 patients between 3 and 60 years of age from Asia (81.3%) or Africa (18.7%) with microscopically confirmed, uncomplicated P. falciparum malaria. Patients underwent randomization for treatment with a fixed-dose combination of 180 mg of pyr...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1056/NEJMoa1007125

Authors


Publisher:
Massachusetts Medical Society
Journal:
New England Journal of Medicine More from this journal
Volume:
366
Issue:
14
Pages:
1298-1309
Publication date:
2012-04-05
DOI:
EISSN:
1533-4406
ISSN:
0028-4793
Pmid:
22475593

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