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Structure of signal-regulatory protein alpha: a link to antigen receptor evolution.

Abstract:

Signal-regulatory protein alpha (SIRPalpha) is a myeloid membrane receptor that interacts with the membrane protein CD47, a marker of self. We have solved the structure of the complete extracellular portion of SIRPalpha, comprising three immunoglobulin superfamily domains, by x-ray crystallography to 2.5 A resolution. These data, together with previous data on the N-terminal domain and its ligand CD47 (possessing a single immunoglobulin superfamily domain), show that the CD47-SIRPalpha intera...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m109.017566

Authors


Hatherley, D More by this author
Graham, SC More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Structural Biology
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Journal:
The Journal of biological chemistry
Volume:
284
Issue:
39
Pages:
26613-26619
Publication date:
2009-09-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:1a8a57ec-3ed1-461f-8d84-b6f4a0cbac84
Source identifiers:
9251
Local pid:
pubs:9251

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