- Abstract:
-
Signal-regulatory protein alpha (SIRPalpha) is a myeloid membrane receptor that interacts with the membrane protein CD47, a marker of self. We have solved the structure of the complete extracellular portion of SIRPalpha, comprising three immunoglobulin superfamily domains, by x-ray crystallography to 2.5 A resolution. These data, together with previous data on the N-terminal domain and its ligand CD47 (possessing a single immunoglobulin superfamily domain), show that the CD47-SIRPalpha intera...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1074/jbc.m109.017566
-
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- Journal:
- The Journal of biological chemistry
- Volume:
- 284
- Issue:
- 39
- Pages:
- 26613-26619
- Publication date:
- 2009-09-05
- DOI:
- EISSN:
-
1083-351X
- ISSN:
-
0021-9258
- URN:
-
uuid:1a8a57ec-3ed1-461f-8d84-b6f4a0cbac84
- Source identifiers:
-
9251
- Local pid:
- pubs:9251
- Language:
- English
- Keywords:
- Copyright date:
- 2009
Journal article
Structure of signal-regulatory protein alpha: a link to antigen receptor evolution.
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