Journal article
Tertiary element interaction in HIV-1 TAR
- Abstract:
- HIV-1 replication requires binding to occur between Trans-activation Response Element (TAR) RNA and the TAT protein. This TAR-TAT binding depends on the conformation of TAR, and therapeutic development has attempted to exploit this dynamic behavior. Here we simulate TAR dynamics in the context of mutations inhibiting TAR binding. We find that two tertiary elements, the apical loop and the bulge, can interact directly, and this interaction may be linked to the affinity of TAR for TAT.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
-
-
(Preview, Accepted manuscript, pdf, 9.3MB, Terms of use)
-
- Publisher copy:
- 10.1021/acs.jcim.6b00152
Authors
+ Agency for Science, Technology and
Research (A*STAR)
More from this funder
- Grant:
- Joint Council Office (JCO) Career Development Award (project number 15302FG145) to A.Y.L.S
+ Engineering and Physical Sciences Research Council
More from this funder
- Grant:
- EP/I017909/1/ to C.M.D
- Publisher:
- American Chemical Society
- Journal:
- Journal of Chemical Information and Modeling More from this journal
- Volume:
- 56
- Issue:
- 9
- Pages:
- 1746-1754
- Publication date:
- 2016-08-08
- Acceptance date:
- 2016-08-08
- DOI:
- EISSN:
-
1549-960X
- ISSN:
-
1549-9596
- Pmid:
-
27500460
- Language:
-
English
- Keywords:
- Pubs id:
-
pubs:638634
- UUID:
-
uuid:1a87c109-bde2-4bb2-9702-acfca95fa641
- Local pid:
-
pubs:638634
- Source identifiers:
-
638634
- Deposit date:
-
2016-10-09
Terms of use
- Copyright holder:
- American Chemical Society
- Copyright date:
- 2016
- Notes:
- Copyright © 2016 American Chemical Society. This is the accepted manuscript version of the article. The final version is available online from the American Chemical Society at: https://doi.org/10.1021/acs.jcim.6b00152
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