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Intratumoral lymphatics are essential for the metastatic spread and prognosis in squamous cell carcinomas of the head and neck region.

Abstract:

Head and neck squamous cell carcinomas (HNSCCs) frequently disseminate to regional lymph nodes. To investigate the possible mechanisms involved, we studied the expression of cancer cell adhesion molecules together with lymphatic vascular and blood vascular markers in a panel of 97 primary HNSCC tumors and correlated expression levels with conventional clinicopathological parameters and with long-term prognosis. In particular, we measured the density of intratumoral and peritumoral lymph vesse...

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Publication status:
Published

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Authors


Luukkaa, M More by this author
Grénman, R More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Molecular Medicine
Jalkanen, S More by this author
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Journal:
Cancer research
Volume:
63
Issue:
8
Pages:
1920-1926
Publication date:
2003-04-05
EISSN:
1538-7445
ISSN:
0008-5472
URN:
uuid:1a77b343-8ade-44eb-8bb4-25212fe12646
Source identifiers:
102443
Local pid:
pubs:102443

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