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Combination of protein and viral vaccines induces potent cellular and humoral immune responses and enhanced protection from murine malaria challenge.

Abstract:

The search for an efficacious vaccine against malaria is ongoing, and it is now widely believed that to confer protection a vaccine must induce very strong cellular and humoral immunity concurrently. We studied the immune response in mice immunized with the recombinant viral vaccines fowlpox strain FP9 and modified virus Ankara (MVA), a protein vaccine (CV-1866), or a combination of the two; all vaccines express parts of the same preerythrocytic malaria antigen, the Plasmodium berghei circums...

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Publication status:
Published

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Publisher copy:
10.1128/iai.00828-07

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Jenner Institute, Biomedical Research Centre
Role:
Author
Journal:
Infection and immunity
Volume:
75
Issue:
12
Pages:
5819-5826
Publication date:
2007-12-05
DOI:
EISSN:
1098-5522
ISSN:
0019-9567
URN:
uuid:1a73126d-9878-4fc4-8f02-e39d326b16ae
Source identifiers:
33992
Local pid:
pubs:33992

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