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The effects of severe hypoxia on glycolytic flux and enzyme activity in a model of solid tumors

Abstract:

Solid tumors contend with, and adapt to, a hostile micro-environment that includes limited availability of nutrient fuels and oxygen. The presence of hypoxia (O2 <5%) stabilizes the transcription factor Hif1 and results in numerous cellular adaptations including increased flux of glucose through glycolysis. Increasingly, more sophisticated analysis of tumor oxygenation has revealed large gradients of oxygen tension and significant regions under severe hypoxia (O2 ∼0.1%). The present invest...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1002/jcb.25488

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, RDM Clinical Laboratory Sciences
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, RDM Clinical Laboratory Sciences
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Publisher:
Wiley Online Library Publisher's website
Journal:
Journal of Cellular Biochemistry Journal website
Volume:
117
Issue:
8
Pages:
1890-1901
Publication date:
2016-02-02
Acceptance date:
2016-01-06
DOI:
EISSN:
1097-4644
ISSN:
0730-2312
URN:
uuid:1a7200b2-73d7-4ba4-aa97-667e5563eddb
Source identifiers:
586501
Local pid:
pubs:586501

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