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Insight into S-adenosylmethionine biosynthesis from the crystal structures of the human methionine adenosyltransferase catalytic and regulatory subunits.

Abstract:

MAT (methionine adenosyltransferase) utilizes L-methionine and ATP to form SAM (S-adenosylmethionine), the principal methyl donor in biological methylation. Mammals encode a liver-specific isoenzyme, MAT1A, that is genetically linked with an inborn metabolic disorder of hypermethioninaemia, as well as a ubiquitously expressed isoenzyme, MAT2A, whose enzymatic activity is regulated by an associated subunit MAT2B. To understand the molecular mechanism of MAT functions and interactions, we have ...

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Publication status:
Published

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Publisher copy:
10.1042/bj20121580

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Structural Genomics Consortium
Role:
Author
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Journal:
The Biochemical journal
Volume:
452
Issue:
1
Pages:
27-36
Publication date:
2013-05-05
DOI:
EISSN:
1470-8728
ISSN:
0264-6021
URN:
uuid:1a70c696-f561-40c1-aec7-7173d01f9ced
Source identifiers:
387113
Local pid:
pubs:387113

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