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Tumour-infiltrating CD8+ lymphocytes and colorectal cancer recurrence by tumour and nodal stage

Abstract:

Background

Intratumoural T-cell infiltrate intensity cortes wrelaith clinical outcome in stage II/III colorectal cancer (CRC). We aimed to determine whether this association varies across this heterogeneous group.


Methods

We performed a pooled analysis of 1804 CRCs from the QUASAR2 and VICTOR trials. Intratumoural CD8+ and CD3+ densities were quantified by immunohistochemistry in tissue microarray (TMA) cores, and their association with clinical outcome analysed...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1038/s41416-019-0540-4

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Doctoral Training Centre
Oxford college:
Green Templeton College
Role:
Author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
Role:
Author
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Funding agency for:
Glaire, MA
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Grant:
C6199/A10417
C399/A2291
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Grant:
Seventh Framework Programme: 258236
EVOCAN
Oxford Cancer Centre More from this funder
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Publisher:
Springer Nature Publisher's website
Journal:
British Journal of Cancer Journal website
Volume:
121
Pages:
474-482
Publication date:
2019-08-07
Acceptance date:
2019-07-18
DOI:
EISSN:
1532-1827
ISSN:
0007-0920
Pubs id:
pubs:1030348
URN:
uri:1a7063af-69fa-4d8b-a174-a4fc1d25f860
UUID:
uuid:1a7063af-69fa-4d8b-a174-a4fc1d25f860
Local pid:
pubs:1030348

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