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Carcinoembryonic antigen (CEA) inhibits NK killing via interaction with CEA-related cell adhesion molecule 1.

Abstract:

The NK killing activity is regulated by activating and inhibitory NK receptors. All of the activating ligands identified so far are either viral or stress-induced proteins. The class I MHC proteins are the ligands for most of the inhibitory NK receptors. However, in the past few years, several receptors have been identified that are able to inhibit NK killing independently of class I MHC recognition. We have previously demonstrated the existence of a novel inhibitory mechanism of NK cell cyto...

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
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Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
174
Issue:
11
Pages:
6692-6701
Publication date:
2005-06-05
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:1a6f54e0-393a-483b-ad16-1f167d5cba73
Source identifiers:
482828
Local pid:
pubs:482828

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