Journal article
Diffusion-weighted MR spectroscopy: consensus, recommendations, and resources from acquisition to modeling
- Abstract:
- Brain cell structure and function reflect neurodevelopment, plasticity, and aging; and changes can help flag pathological processes such as neurodegeneration and neuroinflammation. Accurate and quantitative methods to noninvasively disentangle cellular structural features are needed and are a substantial focus of brain research. Diffusion-weighted MRS (dMRS) gives access to diffusion properties of endogenous intracellular brain metabolites that are preferentially located inside specific brain cell populations. Despite its great potential, dMRS remains a challenging technique on all levels: from the data acquisition to the analysis, quantification, modeling, and interpretation of results. These challenges were the motivation behind the organization of the Lorentz Center workshop on "Best Practices & Tools for Diffusion MR Spectroscopy" held in Leiden, the Netherlands, in September 2021. During the workshop, the dMRS community established a set of recommendations to execute robust dMRS studies. This paper provides a description of the steps needed for acquiring, processing, fitting, and modeling dMRS data, and provides links to useful resources.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 7.2MB, Terms of use)
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- Publisher copy:
- 10.1002/mrm.29877
Authors
+ Wellcome Trust
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- Funder identifier:
- https://ror.org/029chgv08
- Grant:
- 225924/Z/22/Z
- 225924/Z/22/Z
- Publisher:
- Wiley
- Journal:
- Magnetic Resonance in Medicine More from this journal
- Volume:
- 91
- Issue:
- 3
- Pages:
- 860-885
- Place of publication:
- United States
- Publication date:
- 2023-11-09
- Acceptance date:
- 2023-09-08
- DOI:
- EISSN:
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1522-2594
- ISSN:
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0740-3194
- Pmid:
-
37946584
- Language:
-
English
- Keywords:
- Pubs id:
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1564151
- Local pid:
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pubs:1564151
- Deposit date:
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2025-02-19
- ARK identifier:
Terms of use
- Copyright holder:
- Ligneul et al
- Copyright date:
- 2024
- Rights statement:
- © 2023 The Authors. Magnetic Resonance in Medicine published by Wiley Periodicals LLC on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
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