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Evaluating beta-amino acids as enantioselective organocatalysts of the Hajos-Parrish-Eder-Sauer-Wiechert reaction.

Abstract:
A systematic study of the effect of substitution within the beta-amino acid framework indicates that both beta(2)- and beta(3)-amino acids catalyse the Hajos-Parrish-Eder-Sauer-Wiechert reaction with poor to reasonable levels of enantioselectivity. These results led to the evaluation of the conformationally constrained beta-amino acid (1R,2S)-cispentacin, which catalyses the Hajos-Parrish-Eder-Sauer-Wiechert reaction with comparable or higher levels of enantioselectivity to L-proline.
Publication status:
Published

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Publisher copy:
10.1039/b711171a

Authors

More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author


Journal:
Organic and biomolecular chemistry More from this journal
Volume:
5
Issue:
19
Pages:
3190-3200
Publication date:
2007-10-01
DOI:
EISSN:
1477-0539
ISSN:
1477-0520


Language:
English
Keywords:
Pubs id:
pubs:33979
UUID:
uuid:1a64226b-bab0-4caa-9e3e-3994ec60ae9d
Local pid:
pubs:33979
Source identifiers:
33979
Deposit date:
2012-12-19
ARK identifier:

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