Physical activity and lung cancer among non-smokers: a pilot molecular epidemiological study within EPIC.

Journal article

The association between physical activity, potential intermediate biomarkers and lung cancer risk was investigated in a study of 230 cases and 648 controls nested within the European Prospective Investigation of Cancer and Nutrition. Data on white blood cell aromatic-DNA adducts by (32)P-post-labelling and glutathione (GSH) in red blood cells were available from a subset of cases and controls. Compared with the first quartile, the fourth quartile of recreational physical activity was associated with a lower lung cancer risk (odds ratio (OR) 0.56, 95% confidence interval (CI) 0.35-0.90), higher GSH levels (+1.87 micromol GSH g(-1) haemoglobin, p = 0.04) but not with the presence of high levels of adducts (OR 1.05, 95% CI 0.38-2.86). Despite being associated with recreational physical activity, in these small-scale pilot analyses GSH levels were not associated with lung cancer risk (OR 0.95, 95% CI 0.84-1.07 per unit increase in GSH levels). Household and occupational activity was not associated with lung cancer risk or biomarker levels.

Authors: Rundle, A; Richie, J; Steindorf, K; Peluso, M; Overvad, K

• Publication status: Published
• Journal: Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals
• Volume: 15
• Issue: 1
• Pages: 20-30
• Publication date: 2010-02-01
• DOI: 10.3109/13547500903186452
• EISSN: 1366-5804
• ISSN: 1354-750X
• Language: English
• Keywords: Motor Activity; Glutathione; Biological Markers; DNA Adducts; Lung Neoplasms; Case-Control Studies; Female; Erythrocytes; Molecular Epidemiology; Leukocytes; Smoking; Middle Aged; Pilot Projects; Risk Factors; Male; Humans; Aged; Europe