Adjunctive dexamethasone in bacterial meningitis: a meta-analysis of individual patient data.

Journal article

BACKGROUND: Dexamethasone improves outcome for some patients with bacterial meningitis, but not others. We aimed to identify which patients are most likely to benefit from dexamethasone treatment. METHODS: We did a meta-analysis of individual patient data from the randomised, double-blind, placebo-controlled trials of dexamethasone for bacterial meningitis in patients of all ages for which raw data were available. The pre-determined outcome measures were death at the time of first follow-up, ...

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Authors: van de Beek, D; Farrar, J; de Gans, J; Mai, N; Molyneux, E

• Publication status: Published
• Journal: Lancet. Neurology
• Volume: 9
• Issue: 3
• Pages: 254-263
• Publication date: 2010-03-01
• DOI: 10.1016/s1474-4422(10)70023-5
• EISSN: 1474-4465
• ISSN: 1474-4422
• Language: English
• Keywords: Randomized Controlled Trials as Topic; Dexamethasone; Adolescent; Anti-Inflammatory Agents; Young Adult; Drug Therapy, Combination; Child, Preschool; Child; Humans; Adult; Female; Male; Meningitis, Bacterial; Infant; Middle Aged