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Leprosy and the adaptation of human toll-like receptor 1.

Abstract:

Leprosy is an infectious disease caused by the obligate intracellular pathogen Mycobacterium leprae and remains endemic in many parts of the world. Despite several major studies on susceptibility to leprosy, few genomic loci have been replicated independently. We have conducted an association analysis of more than 1,500 individuals from different case-control and family studies, and observed consistent associations between genetic variants in both TLR1 and the HLA-DRB1/DQA1 regions with susce...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.ppat.1000979

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Institution:
University of Oxford
Role:
Author
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Institution:
University of Oxford
Role:
Author
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Institution:
University of Oxford
Role:
Author
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Funding agency for:
Chapman, SJ
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Funding agency for:
Vannberg, FO
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Publisher:
Public Library of Science Publisher's website
Journal:
PLoS pathogens Journal website
Volume:
6
Issue:
7
Pages:
e1000979
Publication date:
2010-01-01
DOI:
EISSN:
1553-7374
ISSN:
1553-7366
URN:
uuid:1a3d3016-3345-4f8b-a6e3-216be9069280
Source identifiers:
65274
Local pid:
pubs:65274

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