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Liver Kupffer cells control the magnitude of the inflammatory response in the injured brain and spinal cord.

Abstract:

The CNS inflammatory response is regulated by hepatic chemokine synthesis, which promotes leukocytosis and facilitates leukocyte recruitment to the site of injury. To understand the role of the individual cell populations in the liver during the hepatic response to acute brain injury, we selectively depleted Kupffer cells (KC), using clodronate-filled liposomes, and assessed the inflammatory response following a microinjection of IL-1beta into the rat brain or after a compression injury in th...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Role:
Author
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Journal:
Neuropharmacology
Volume:
55
Issue:
5
Pages:
780-787
Publication date:
2008-10-05
DOI:
EISSN:
1873-7064
ISSN:
0028-3908
URN:
uuid:1a385252-6c7e-415d-b752-10c27ffc18d1
Source identifiers:
185206
Local pid:
pubs:185206

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