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The dopamine hypothesis of Bipolar Affective Disorder: the state of the art and implications for treatment

Abstract:

Bipolar affective disorder is a common neuropsychiatric disorder. Whilst its neurobiological underpinnings are incompletely understood, the dopamine hypothesis has been a key theory of the pathophysiology of both manic and depressive phases of the illness for over four decades. The increased use of antidopaminergics in the treatment of this disorder and new in vivo neuroimaging and post-mortem studies makes it timely to review this theory. To do this, we conducted a systematic search for po...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/mp.2017.16

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Institution:
University of Oxford
Oxford college:
Merton College
Role:
Author
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National Institute of Health Research More from this funder
Medical Research Council More from this funder
Wellcome Trust More from this funder
Maudsley Charity More from this funder
Publisher:
Nature Publishing Group Publisher's website
Journal:
Molecular Psychiatry Journal website
Volume:
22
Pages:
666–679
Publication date:
2017-03-14
Acceptance date:
2017-01-08
DOI:
EISSN:
1476-5578
ISSN:
1359-4184
Source identifiers:
670816
Keywords:
Pubs id:
pubs:670816
UUID:
uuid:1a362295-7c90-47f9-9c37-a225ad90c86c
Local pid:
pubs:670816
Deposit date:
2017-01-13

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