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The role of the angiogenic molecule VEGF in the pathogenesis of rheumatoid arthritis.

Abstract:

The expansion of the synovial lining of joints in rheumatoid arthritis (RA), and the subsequent invasion by the pannus of underlying cartilage and bone, necessitates an increase in the vascular supply to the synovium, to cope with the increased requirement for oxygen and nutrients. New blood vessel formation - 'angiogenesis' - is now recognised as a key event in the formation and maintenance of the pannus in RA. Although many pro-angiogenic factors have been demonstrated to be expressed in RA...

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Publication status:
Published

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Authors


Afuwape, AO More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Paleolog, EM More by this author
Journal:
Histology and histopathology
Volume:
17
Issue:
3
Pages:
961-972
Publication date:
2002
EISSN:
1699-5848
ISSN:
0213-3911
URN:
uuid:1a32098f-135e-441f-bc98-dd04ba12af4a
Source identifiers:
229626
Local pid:
pubs:229626

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