Participation of DNA-PKcs in DSB repair after exposure to high- and low-LET radiation.

Journal article

Cellular lesions (e.g. DSBs) are induced into DNA upon exposure to radiation, with DSB complexity increasing with radiation ionization density. Using M059K and M059J human glioblastoma cells (proficient and deficient in DNA-PKcs activity, respectively), we investigated the repair of DNA damage, including DSBs, induced by high- and low-LET radiation [gamma rays, alpha particles and high-charge and energy (HZE) ions]. In the absence of DNA-PKcs activity, less DSB repair and increased recruitmen...

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Authors: Anderson, J; Harper, J; Cucinotta, F; O'Neill, P

• Publication status: Published
• Journal: Radiation research
• Volume: 174
• Issue: 2
• Pages: 195-205
• Publication date: 2010-08-01
• DOI: 10.1667/rr2071.1
• EISSN: 1938-5404
• ISSN: 0033-7587
• Language: English
• Keywords: Gamma Rays; Radiation Dosage; Protein Kinase C; DNA Breaks, Double-Stranded; DNA Repair; Cell Line, Tumor; Fibroblasts; DNA-Activated Protein Kinase; Glioblastoma; Iron Radioisotopes; Electrophoresis, Gel, Pulsed-Field; Humans