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Participation of DNA-PKcs in DSB repair after exposure to high- and low-LET radiation.

Abstract:

Cellular lesions (e.g. DSBs) are induced into DNA upon exposure to radiation, with DSB complexity increasing with radiation ionization density. Using M059K and M059J human glioblastoma cells (proficient and deficient in DNA-PKcs activity, respectively), we investigated the repair of DNA damage, including DSBs, induced by high- and low-LET radiation [gamma rays, alpha particles and high-charge and energy (HZE) ions]. In the absence of DNA-PKcs activity, less DSB repair and increased recruitmen...

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Publication status:
Published

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Publisher copy:
10.1667/rr2071.1

Authors


Anderson, JA More by this author
Harper, JV More by this author
Cucinotta, FA More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Journal:
Radiation research
Volume:
174
Issue:
2
Pages:
195-205
Publication date:
2010-08-05
DOI:
EISSN:
1938-5404
ISSN:
0033-7587
URN:
uuid:1a060da5-b178-45de-8a37-87dcd80a4544
Source identifiers:
130947
Local pid:
pubs:130947

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