Journal article
A mechanism of sialylation functionally silences the hyaluronan receptor LYVE-1 in lymphatic endothelium.
- Abstract:
-
The major lymphatic endothelial hyaluronan receptor LYVE-1, a Link superfamily glycoprotein similar to the hyaluronan-binding/inflammatory leukocyte homing receptor CD44, was initially implicated in hyaluronan (HA)-mediated cell adhesion and lymph-borne hyaluronan metabolism. However, the apparently normal phenotype of Lyve-1 knock-out mice and the recent demonstration that the receptor undergoes cytokine-induced endocytosis independent of HA uptake have cast doubt on such functions. Here we ...
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- Publication status:
- Published
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- Publisher copy:
- 10.1074/jbc.m805105200
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Bibliographic Details
- Journal:
- Journal of biological chemistry
- Volume:
- 284
- Issue:
- 6
- Pages:
- 3935-3945
- Publication date:
- 2009-02-01
- DOI:
- EISSN:
-
1083-351X
- ISSN:
-
0021-9258
- Source identifiers:
-
102713
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:102713
- UUID:
-
uuid:19ff411d-8d7e-4fdb-abd0-5d015e6bb8d0
- Local pid:
- pubs:102713
- Deposit date:
- 2012-12-19
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- Copyright date:
- 2009
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