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A mechanism of sialylation functionally silences the hyaluronan receptor LYVE-1 in lymphatic endothelium.

Abstract:

The major lymphatic endothelial hyaluronan receptor LYVE-1, a Link superfamily glycoprotein similar to the hyaluronan-binding/inflammatory leukocyte homing receptor CD44, was initially implicated in hyaluronan (HA)-mediated cell adhesion and lymph-borne hyaluronan metabolism. However, the apparently normal phenotype of Lyve-1 knock-out mice and the recent demonstration that the receptor undergoes cytokine-induced endocytosis independent of HA uptake have cast doubt on such functions. Here we ...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m805105200

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Journal:
Journal of biological chemistry
Volume:
284
Issue:
6
Pages:
3935-3945
Publication date:
2009-02-01
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
Source identifiers:
102713

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