The major lymphatic endothelial hyaluronan receptor LYVE-1, a Link superfamily glycoprotein similar to the hyaluronan-binding/inflammatory leukocyte homing receptor CD44, was initially implicated in hyaluronan (HA)-mediated cell adhesion and lymph-borne hyaluronan metabolism. However, the apparently normal phenotype of Lyve-1 knock-out mice and the recent demonstration that the receptor undergoes cytokine-induced endocytosis independent of HA uptake have cast doubt on such functions. Here we ...Expand abstract
- Publication status:
- Publisher copy:
- Copyright date:
A mechanism of sialylation functionally silences the hyaluronan receptor LYVE-1 in lymphatic endothelium.
Views and Downloads
If you are the owner of this record, you can report an update to it here: Report update to this record