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Effects of ageing on the behavioural responses to dopamine agonists: decreased yawning and locomotion, but increased stereotypy.

Abstract:

Sensorimotor function and the behavioural responses to a range of doses of subcutaneous apomorphine were assessed in mature (6-8 months) and old (23-26 months) Sprague-Dawley rats of comparable weight. In addition, the locomotor activity response of 12-month-old and 24-month-old rats to continuous infusions (14 days by osmotic minipump) of a selective dopamine D2 agonist. (+)-4-propyl-9-hydroxynaphthoxazine (PHNO, 10 micrograms/h) was investigated. Measures of spontaneous locomotor activity a...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Experimental Psychology
Role:
Author
Journal:
Brain research
Volume:
495
Issue:
1
Pages:
20-30
Publication date:
1989-08-05
DOI:
EISSN:
1872-6240
ISSN:
0006-8993
URN:
uuid:19fa2fc9-79e3-44c1-b59e-0690e25895e9
Source identifiers:
28380
Local pid:
pubs:28380

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