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Following nerve injury neuregulin-1 drives microglial proliferation and neuropathic pain via the MEK/ERK pathway.

Abstract:

Following peripheral nerve injury microglia accumulate within the spinal cord and adopt a proinflammatory phenotype a process which contributes to the development of neuropathic pain. We have recently shown that neuregulin-1, a growth factor released following nerve injury, activates erbB 2, 3, and 4 receptors on microglia and stimulates proliferation, survival and chemotaxis of these cells. Here we studied the intracellular signaling pathways downstream of neuregulin-1-erbB activation in mic...

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Publisher copy:
10.1002/glia.21124

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Journal:
Glia
Volume:
59
Issue:
4
Pages:
554-568
Publication date:
2011-04-05
DOI:
EISSN:
1098-1136
ISSN:
0894-1491
URN:
uuid:19e6fbe0-3b35-427b-a1e3-3d349155c7a3
Source identifiers:
365764
Local pid:
pubs:365764

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