Glycophorin C (CD236R) mediates vivax malaria parasite rosetting to normocytes.

Journal article

Rosetting phenomenon has been linked to malaria pathogenesis. Although rosetting occurs in all causes of human malaria, most data on this subject has been derived from Plasmodium falciparum. Here, we investigate the function and factors affecting rosette formation in Plasmodium vivax. To achieve this, we used a range of novel ex vivo protocols to study fresh and cryopreserved P vivax (n = 135) and P falciparum (n = 77) isolates from Thailand. Rosetting is more common in vivax than falciparum ...

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Authors: Lee, W; Malleret, B; Lau, Y; Mauduit, M; Fong, M

• Publication status: Published
• Publisher: American Society of Hematology
• Journal: Blood
• Volume: 123
• Issue: 18
• Pages: e100-e109
• Publication date: 2014-05-01
• DOI: 10.1182/blood-2013-12-541698
• EISSN: 1528-0020
• ISSN: 0006-4971
• Language: English
• Keywords: Animals; Plasmodium vivax; Rosette Formation; Malaria, Vivax; Workflow; Antibodies, Monoclonal; Glycophorin; Gene Knockdown Techniques; Erythrocytes; Humans; Receptors, Complement 3b; Cryopreservation