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Journal article

Fluid and mass transport modelling to drive the design of cell-packed hollow fibre bioreactors for tissue engineering applications.

Abstract:

A model for fluid and mass transport in a single module of a tissue engineering hollow fibre bioreactor (HFB) is developed. Cells are seeded in alginate throughout the extra-capillary space (ECS), and fluid is pumped through a central lumen to feed the cells and remove waste products. Fluid transport is described using Navier-Stokes or Darcy equations as appropriate; this is overlaid with models of mass transport in the form of advection-diffusion-reaction equations that describe the distribu...

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Publication status:
Published

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Publisher copy:
10.1093/imammb/dqr025

Authors


Shipley, RJ More by this author
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Institution:
University of Oxford
Department:
Oxford, MPLS, Mathematical Inst
Journal:
Mathematical medicine and biology : a journal of the IMA
Volume:
29
Issue:
4
Pages:
329-359
Publication date:
2012-12-05
DOI:
EISSN:
1477-8602
ISSN:
1477-8599
URN:
uuid:19cbd69c-1ece-42df-af62-7e2ff2a9483b
Source identifiers:
206088
Local pid:
pubs:206088

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