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Multiplexed SNP typing of ancient DNA clarifies the origin of Andaman mtDNA haplogroups amongst South Asian tribal populations

Abstract:

The issue of errors in genetic data sets is of growing concern, particularly in population genetics where whole genome mtDNA sequence data is coming under increased scrutiny. Multiplexed PCR reactions, combined with SNP typing, are currently under-exploited in this context, but have the potential to genotype whole populations rapidly and accurately, significantly reducing the amount of errors appearing in published data sets. To show the sensitivity of this technique for screening mtDNA ge...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pone.0000081

Authors


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Institution:
University of Oxford
Department:
Mathematical, Physical & Life Sciences Division - Zoology
Mait Metspalu More by this author
Chris Stringer More by this author
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Department:
Department of Statistics
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Department:
Australian Centre for Ancient DNA
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Publisher:
Public Library of Science Publisher's website
Journal:
PLoS ONE Journal website
Volume:
1
Issue:
1
Pages:
Article: e81
Publication date:
2006
DOI:
EISSN:
1932-6203
URN:
uuid:19c1040f-c7f0-4bca-9c85-391cfe860eb9
Local pid:
ora:9580

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