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Gut dysbiosis in severe mental illness and chronic fatigue: a novel trans-diagnostic construct? A systematic review and meta-analysis

Abstract:

Reduced gut-microbial diversity (“gut dysbiosis”) has been associated with an anhedonic/amotivational syndrome (“sickness behavior”) that manifests across severe mental disorders and represent the key clinical feature of chronic fatigue. In this systematic review and meta-analysis, we investigated differences in proxy biomarkers of gut dysbiosis in patients with severe mental illness and chronic fatigue vs. controls and the association of these biomarkers with sickness behavior across diag...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41380-021-01032-1

Authors


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Institution:
University of Oxford
Role:
Author
More by this author
Institution:
University of Oxford
Role:
Author
ORCID:
0000-0001-5563-4893
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Psychiatry
Oxford college:
All Souls College
Role:
Author
ORCID:
0000-0002-4972-8786
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Psychiatry
Role:
Author
ORCID:
0000-0002-6374-8054
More by this author
Institution:
University of Oxford
Role:
Author
ORCID:
0000-0002-6309-6324
Publisher:
Springer Nature
Journal:
Molecular Psychiatry More from this journal
Volume:
27
Issue:
1
Pages:
141-153
Publication date:
2021-02-08
Acceptance date:
2021-01-13
DOI:
EISSN:
1476-5578
ISSN:
1359-4184
Pmid:
33558650
Language:
English
Keywords:
Subtype:
Review
Pubs id:
1161318
Local pid:
pubs:1161318
Deposit date:
2022-11-23

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