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Alternating vector immunizations encoding pre-erythrocytic malaria antigens enhance memory responses in a malaria endemic area.

Abstract:

A heterologous prime-boost strategy has been developed to potently induce T cell responses to pre-erythrocytic malaria antigens. Efficacy in the field is likely to depend on both peak immunogenicity and the durability of responses. To improve both immunogenicity and durability of responses, 54 adult males from a malaria endemic area were immunized with different vaccination regimens, systematically varying antigenic insert and the number and sequence of component vaccinations. The component v...

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Publication status:
Published

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Publisher copy:
10.1002/eji.200636187

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Jenner Institute
Mwacharo, J More by this author
Keating, S More by this author
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Journal:
European journal of immunology
Volume:
36
Issue:
8
Pages:
2264-2272
Publication date:
2006-08-05
DOI:
EISSN:
1521-4141
ISSN:
0014-2980
URN:
uuid:19b57cc9-11fa-4fd3-8f07-62e9dd55ce25
Source identifiers:
40103
Local pid:
pubs:40103

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